Backup running back Derrius Guice rushed for 163 yards and three first-half touchdowns in leading LSU to a 42-7 rout of Missouri Saturday night. (USA Today Sports) 

BATON ROUGE, La. – What happened to the Missouri Tigers on Saturday night might best be described in one six-word phrase: Be careful what you wish for.

The Tigers learned before their game against LSU that running back Leonard Fournette, a Heisman Trophy candidate, would not play because of a lingering ankle injury.

Instead of that development helping the Tigers, however, the loss of Fournette led to breakout games from not one but two LSU running backs as they ran all over the Tigers en route to a 42-7 blowout victory.

Sophomore Darius Guice, Fournette’s backup, rushed for 163 yards on just 17 carries and scored three first-half touchdowns. Darrel Williams added 130 yards on 23 carries and also scored three times. In total, LSU gained 418 yards on the ground in handing Missouri its most lopsided loss since 2008.

“They handed it to us in every area,” said Missouri coach Barry Odom. “I didn’t see a lot of positives tonight. We’ve got to learn from good and bad and tonight obviously was bad.”

Making their first trip ever to LSU, Missouri ran into a fired up team upset by the firing of coach Les Miles and offensive coordinator Cam Cameron, and they took out their anger on both sides of the football.

LSU rolled to a 35-0 lead before Missouri scored its only points of the game, on a trick play, with Eric Laurent throwing a pass on a double reverse to a wide open Drew Lock for a 21-yard touchdown with just 6:11 left in the game.

Other than catching the touchdown, Lock had a rough night, completing just 17 of 37 passes for 167 yards. He also threw one interception.

Missouri could not run the ball on the LSU defense either, gaining just 77 yards on 23 carries.

LSU ran 22 more offensive plays than Missouri, dominated the time of possession and piled up 634 yards of total offense, the most they have ever gained in an SEC game.

The loss dropped Missouri to 0-2 in the SEC and 2-3 overall. They will have their bye week next Saturday, then play at Florida on Oct. 15.